Zepbound

Zepbound (tirzepatide) is a once-weekly injectable medication that can help support weight loss by reducing appetite, increasing feelings of fullness, and helping individuals consume fewer calories. When combined with healthy lifestyle changes, including nutrition and physical activity, Mounjaro has been shown to produce significant and sustained weight loss in clinical studies.

According to the updated Canadian Adult Obesity Clinical Practice Guidelines, tirzepatide (Zepbound®) is one of the most effective medications currently available for chronic weight management when combined with healthy lifestyle changes. Clinical trials have demonstrated average weight loss of approximately 15–22% of initial body weight, depending on the dose used and duration of treatment.

Individual results vary, and some people achieve even greater weight loss. The goal of treatment is not simply a lower number on the scale, but improvements in overall health, including blood sugar control, blood pressure, sleep apnea, mobility, quality of life, and other weight-related health conditions.

As with all obesity treatments, the best results are seen when medication is combined with sustainable nutrition, physical activity, sleep optimization, and ongoing medical support. Long-term treatment is often recommended to help maintain weight loss and prevent weight regain.

Common Side Effects of Tirzepatide (Mounjaro® / Zepbound®)

Tirzepatide works on both GLP-1 and GIP receptors and has a side effect profile similar to semaglutide, with gastrointestinal symptoms being the most common. These symptoms often improve over time and are most common when doses are increased.

Common Side Effects

Nausea
Vomiting
Diarrhea
Constipation
Abdominal pain
Indigestion or heartburn
Bloating, gas, or burping
Decreased appetite
Fatigue
Dizziness
Hair thinning or hair loss
Injection site reactions

Less Common but Serious Side Effects

Pancreatitis
Gallbladder disease
Kidney injury related to dehydration
Severe stomach or gastrointestinal problems
Severe allergic reactions
Low blood sugar (particularly when used with certain diabetes medications)
Possible risk of thyroid C-cell tumors (seen in animal studies; relevance to humans remains unknown)

Most people tolerate tirzepatide well, and side effects can often be managed with gradual dose increases, hydration, and dietary modifications.

Obesity is a chronic medical condition, and long-term management is often needed to support lasting results. During your consultation, Tanya will review whether Zepbound may be an appropriate option for you and discuss realistic expectations based on your medical history, symptoms, and weight management goals.